Studies: Alterations of norepinephrine and other neurotransmitters may affect the creative process. The minds of exceptionally creative people may be capable of regulating norepinephrine – to decrease levels during periods of creative innovation and pave the way for discovery of unanticipated associations. High levels of norepinephrine constrict the diversity of available concepts; low levels have the opposite effect. (Heilman, K. M. Creative Innovation: Possible Brain Mechanisms. 9(5):369-379. Neurocase. 2003.)

Studies: people involved in creative activities tend to have a greater incidence of psychopathology (e.g., mood disorders, bipolarity, major depressive disorder) as compared with the general population. (Fairweather, Elizabeth. Creativity and Bipolarity.)