Studies over three (3) decades: Structural and functional brain changes occur with repeated drug abuse. Extensive brain changes can include damage to nerve cells and altered biochemical mechanisms in communication pathways. (Zickler, Patrick. Acute Dopamine Surge May Erode Resolve to Abstain. MD: National Institute on Drug Abuse, NIDA NOTES, Vol 19, No 1, April, 2004, pp S1-S16)

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