Effects of Corticotropin Releasing Factor or CRF in limbic brain regions have been associated with increased fear, alertness, decreased appetite and libido, all functions relevant in the fight or flight response and dysregulated in depression and anxiety disorders. Overactivity of the CRF/CRF1 receptor system has been demonstrated to be one of the long term neurobiological sequelae of early life trauma, a major risk factor for the development of affective disorders. In fact, both rodents and non-human primates exposed to adverse experiences in early life exhibit evidence of hyperactivity of the CRF system as adults. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666571/)