Discovered about 1930, Substance p is involved in the transmission of pain impulses from the spinal cord to the brain. Released in the skin, you feel pain; in the brain you feel anxiety and depression (opposite effects to Neuropeptide Y.) Capsaicin is a blocker. (Perricone, Nicholas, MD. The Perricone Promise. p 24-25. NY: Warner Books, 2004.)

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