Originally used as an animal anesthetic and now used as a short-acting anesthetic in humans, ketamine is mediated directly through neurons in the hippocampus (involved with memory functions). This drug “doesn’t just zap memory a bit—it wipes it out completely for most of the ‘trip’.” (Giuffre, Kenneth, MD. The Care and Feeding of Your Brain. p 56-57. NJ: Career Press, 1999.)

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