Psychadelics (e.g., LDS, MDMA or Ecstasy, PCP, Special K) initially enhance dopamine and serotonin release. With chronic or high-dose usage however, the brain “spaces out” due to depleted levels of serotonin and a toxic effect on dopamine neurons. (Guiffre, Kenneth, MD, with Theresa Foy DiGeronimo. The Care and Feeding of Your Brain. p 33-39. NJ:Career Press, 1999.)