Explains how some addictive substances are likely designed to work (e.g., LSD blocks serotonin receptors). (Brynie, Faith Hickman. 101 Questions Your Brain Has Asked About Itself But Couldn’t Answer, Until Now. CT: Millbrook Press, 1998, pp 150-151)

Any substance that creates dependence (e.g., opium, nicotine, cocaine, alcohol, marijuana) does so by exerting direct pharmacologic effects on the brain, specifically on areas involved in mood. (Restak, Richard, MD. The Brain has a Mind of its Own. pp 41-44. NY: Crown Publishers, Inc. 1991.)

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