Prion disease (e.g., Kuru, CJD or Cruetzfeldt-Jakob disease and vCJD, mad cow, scrapie, bovine spongiform encephalopathy or BSE) is a disease of glia as much as of neurons. Astrocytes infected with the diseased prior release cytokines and neurotoxic agents and neurons die as a result. When oligodendrocytes becomes diseased, the myelin sheath insulating axons suffers damage. In response to prion infection, microglia seek out and selectively kill neurons in prion disease. Note: PrP is a normal protein in neurons that becomes mutated and infectious in prion disease.(Fields, R. Douglas, PhD. The Other Brain. p 124-130. NY: Simon & Schuster, 2009.)

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